限制使用πn 1_2 and 1_3

Hi

I came across a custom board design around the Da14580 which has something peculiar in it's schematic. It states that "P1_2 and P1_3 cannot be toggled when 16 MHz XTAL is" .(the last word is cut off).

Is there any restriction on using pin 1_2 and 1_3 ? Is there any special dependency on the XTAL or some other peripheral ?

I tried looking for this in the datasheet but didn't find anything

Can I safely use it in my design for I2C ?

Thanks,