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Thanks, Dialog.
The scatter config file defines several spaces, and I did a little change based on the sdk 5.0.5 ble_example project. In order to get more ram space for code RO and Data RO, I rearrange the ram setting. Could you help check it please? Before I added some new features in our project, this can work well using .hex flashing. But after the size gets larger, I was stuck by this problem.
For some big array initialization, I declare them as '__attribute__((section("retention_mem_area0"),zero_init)); ' to put them in the retention ram.

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# !armcc - e -我,\.\..,.\..\src\config,.\..\..\sdk\common_project_files\ --cpu Cortex-M0

#include "da1458x_config_basic.h"
#include "da1458x_config_advanced.h"
#include "da1458x_scatter_config.h"

; *************************************************************
; *** Scatter-Loading Description File generated by uVision ***
; *************************************************************
;
; This scatter file is set up for EM_MAP == 23!
; If an application uses a different memory layout then it must
; use a customized scatter file.
;**************************************************************

LR_IROM1 0 x20000000 0 x160 {;负荷地区size_region
ER_IROM1 0x20000000 0x160 { ; load address = execution address
*.o (RESET, +First)
}
}

LR_IROM2 0x20000160 0x160 {
ER_IROM2 0x20000160 0x160 {
* (jump_table_mem_area)
}
}

LR_IROM3 0x200002C0 0x80 {
ER_IROM3 0x200002C0 0x80 {
* (timeout_table_area)
}
}

LR_IROM4 0x20000340 0x100 {
ER_IROM4 0x20000340 0x100 {
* (nvds_data_storage_area)
}
}

LR_IROM5 0x20000440 0x93c0 {
ER_IROM5 0x20000440 0x8dc0 {
*(InRoot$$Sections) ; All library sections that must be in a
; root region, for example, __main.o,
; __scatter*.o, __dc*.o, and * Region$$Table
boot_vectors.o (+RO)
system_ARMCM0.o (+RO)
;*armlib* (+RO)
.ANY (+RO)
.ANY (+ RW)
}

RW_IRAM54 0x20009200 UNINIT 0x600 { ; Stack
.ANY (STACK)
}

}

LR_RETENTION_RAM2 0x00080768 0x2898 {
; Extended Sleep mode
; Extended RetRAM : 0x80000 - 0x83000
ZI_RET20 0x00080768 UNINIT 0x22b8 { ; 0x80768 is the last address used by the ROM code
#if (BLE_CONNECTION_MAX_USER > 4)
arch_system.o (cs_area)
#endif
jump_table.o (heap_env_area)
jump_table.o (heap_db_area)
jump_table.o (heap_msg_area)
.ANY (retention_mem_area0) ; application data
.ANY (+ZI)
#if defined(SPOTAR_PATCH_AREA) && (SPOTAR_PATCH_AREA == 1)
app_spotar.o (spotar_patch_area) ; Placed in the SysRAM when SPOTAR_PATCH_SYSRAM is 1
#endif
}

ZI_RET21 EXCHANGE_MEMORY_BASE EXCHANGE_MEMORY_SIZE {
arch_main.o (BLE_exchange_memory)
}
}
#endif

;LR_GUARD_RAM 0x50000000 0x0 {
;RW_GRAM0 0x50000000 0x0 { ; Make sure that nothing has been placed in here!
;*.o (exchange_mem_case1)
;}
;}